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The Use of Imaging Tools in Toxicology Assessments

In the last decade, in vivo imaging methods have become established tools in basic science research. This lecture is designed provide a general overview of ultrasound imaging utilized in basic science with applications to drug discovery and toxicological research. Five cardiovascular models will be described as examples including: myocardial hypertrophy, myocardial infarction, Marfan's disease, atherosclerosis and cancer therapy-induced cardiac injury. The second half of the presentation will focus on the use of ultrasound for cancer studies to measure tumor volume, tumor blood flow and gene expression of tumor blood vessels. Following this short review, attendees should have basic understanding of the various ultrasound imaging applications used in cardiovascular disease drug discovery, toxicological and cancer research.

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